Scientists may have discovered the mechanisms behind aging!


Is aging history, will we age later than usual?  Hear this!

Researchers at Salk Institute and Chinese Academy of Science have already quoted in a scientific paper that they may have discovered the DNA methods of preventing and treating age-related illnesses such as cancer, diabetes and Alzheimer’s.

Scientists suggest that genetic mutations underlying Werner syndrome, a disorder that leads to premature aging and death, resulted in the deterioration of bundles of DNA known as heterochromatin. The discovery, made possible through a combination of cutting-edge stem cell and gene-editing technologies, could lead to ways of countering age-related physiological declines by preventing or reversing damage to heterochromatin.

Werner Syndrome & Heterochromatin

As a genetic disorder, Werner Syndrome causes people to age more rapidly than normal. It affects around one in every 200,000 people in the U.S. People with the disorder suffer age-related diseases early in life, including cataracts, type 2 diabetes, hardening of the arteries, osteoporosis and cancer, and most die in their late 40s or early 50s.

The emergence of this particular disease is caused by a mutation to the Werner syndrome RecQ helicase-like gene (the “WRN gene”), which generates the WRN protein. Previous studies showed that the normal form of the protein is an enzyme that maintains the structure and integrity of a person’s DNA. When the protein is mutated in Werner syndrome it disrupts the replication and repair of DNA and the expression of genes, which was thought to cause premature aging. However, it was unclear exactly how the mutated WRN protein disrupted these critical cellular processes.

A senior author on the paper, Juan Carlos Izpisua Belmonte says:

“Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general disruption of cellular processes by disrupting epigenetic regulation,”

“More broadly, it suggests that accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular aging. This [raises] the question of whether we can reverse these alterations — like remodeling an old house or car — to prevent, or even reverse, age-related declines and diseases.”

Senior Researcher Belmonte added that more extensive studies will be needed to fully understand the role of heterochromatin disorganization in aging, including how it interacts with other cellular processes implicated in aging, such as shortening of the end of chromosomes, known as telomeres. In addition, the Belmonte team is developing epigenetic editing technologies to reverse epigenetic alterations with a role in human aging and disease.

The study was funded by the Glenn Foundation, the G. Harold and Leila Y. Mathers Charitable Foundation and the Leona M. and Harry B. Helmsley Charitable Trust.

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